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Call us to book on 0203 960 7960

Our lines are open everyday from
8:30am – 9:30pm

Get to know about Second Trimester Prenatal screening tests

Pregnancy is an incredible journey filled with anticipation and excitement, but it also comes with a great responsibility to ensure the well-being of both the mother and the developing baby. Prenatal screening tests play a vital role in assessing the health and development of the fetus. In this blog, Ultrasound plus will explore the second trimester of pregnancy and delve into the various prenatal screening tests available during this crucial period.

Overview of the Second Trimester:

The second trimester, spanning from week 13 to week 28, is often considered the golden period of pregnancy. It is a time of significant growth and development for the baby, accompanied by various changes experienced by the mother. As the baby’s organs continue to form, this trimester becomes an ideal window for prenatal screening to detect any potential abnormalities.

Types of Second Trimester Prenatal Screening Tests:

Maternal Serum Screening:

Maternal Serum Screening, also known as Triple or Quadruple Marker Screening, involves analyzing the mother’s blood to assess specific markers and substances. These markers include alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), estriol, and inhibin-A. This test provides valuable information regarding the baby’s risk for chromosomal abnormalities and neural tube defects. However, it is important to note that it is a screening test and not a diagnostic one.

Anatomy Ultrasound Scan:

One of the most anticipated and informative tests during the second trimester is the Anatomy Ultrasound Scan. This non-invasive procedure utilizes high-frequency sound waves to create detailed images of the baby’s anatomy.

It allows healthcare professionals to evaluate the development of organs, detect any physical abnormalities, and assess the placenta, amniotic fluid levels, and the baby’s position. This scan also provide an opportunity for parents to bond with their unborn child as they witness their baby’s movements and hear the reassuring sound of the heartbeat.

Triple or Quadruple Marker Screening

Triple or Quadruple Marker Screening, also known as multiple marker screening or maternal serum screening, is a prenatal screening test conducted during the second trimester of pregnancy. It involves analyzing specific substances or markers in the mother’s blood to assess the risk of certain genetic abnormalities and structural defects in the developing baby.

The name “Triple Marker” refers to the analysis of three markers: alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and estriol. In some cases, a fourth marker called inhibin-A is included, resulting in the term “Quadruple Marker Screening.” These markers are produced by the baby and the placenta and can provide valuable information about the baby’s health.

Additional Diagnostic Tests:


Amniocentesis is a diagnostic test that involves withdrawing a small amount of amniotic fluid for analysis. This test is typically offered if there is an increased risk of chromosomal abnormalities or genetic disorders based on the results of previous screenings or medical history. It provides a more definitive diagnosis but carries a small risk of complications.

Chorionic Villus Sampling (CVS):

Chorionic Villus Sampling (CVS) is another diagnostic test performed during the second trimester. It involves collecting a small sample of tissue from the placenta to assess genetic abnormalities. CVS carries some risks like amniocentesis, but it can provide crucial information about the baby’s health.

Counseling and Decision-Making:

When considering prenatal screening tests, it is essential for expectant parents to engage in informed decision-making. Genetic counseling plays a vital role in this process, providing a supportive environment to discuss the benefits, risks, and implications of these tests. It is crucial to consider personal values, beliefs, and individual circumstances when making decisions about which tests to pursue.


The second trimester of pregnancy is a remarkable time when the baby’s development reaches significant milestones. Prenatal screening tests during this period enable healthcare professionals to identify potential issues and provide appropriate care. Understanding the purpose, benefits, and limitations of these tests Ultrasound plus empowers expectant parents to make informed choices, fostering the well-being of both the mother and the baby. Remember to consult with your healthcare provider and seek their guidance throughout this journey, ensuring a healthy pregnancy and a bright future for your growing family.

Experience exceptional Second Trimester Prenatal screening services. Call us now to speak with our knowledgeable team and schedule an appointment.